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CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.

ABSTRACT: OBJECTIVE: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS: Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. RESULTS: We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. CONCLUSION: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.

SUBMITTER: Deng L

PROVIDER: S-EPMC3816826 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.

Deng Lijing L Zhou Haixia H Yang Jing J Xiao Jun J Wang Bo B Wang Lan L Ou Xuemei X Feng Yulin Y

International journal of clinical and experimental pathology 20131015 11

<h4>Objective</h4>The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population.<h4>Methods</h4>Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed usi ...[more]

PMID: 24228119

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