Ontology highlight
ABSTRACT:
SUBMITTER: Gilbert MR
PROVIDER: S-EPMC3816958 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Gilbert Mark R MR Wang Meihua M Aldape Kenneth D KD Stupp Roger R Hegi Monika E ME Jaeckle Kurt A KA Armstrong Terri S TS Wefel Jeffrey S JS Won Minhee M Blumenthal Deborah T DT Mahajan Anita A Schultz Christopher J CJ Erridge Sara S Baumert Brigitta B Hopkins Kristen I KI Tzuk-Shina Tzahala T Brown Paul D PD Chakravarti Arnab A Curran Walter J WJ Mehta Minesh P MP
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20131007 32
<h4>Purpose</h4>Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of treatment response. Dose-dense (DD) temozolomide results in prolonged depletion of MGMT in blood mononuclear cells and possibly in tumor. This trial tested whether DD temozolomide improves overall survival (OS) or progression-free survival (PFS) in patients with ...[more]