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Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity.

ABSTRACT: Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe autoimmune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peritumoral delivery of low doses of this immunomodulatory drug can trigger a systemic antitumor immune response while preventing the toxicity against other organs.

SUBMITTER: Marabelle A

PROVIDER: S-EPMC3817012 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity.

Marabelle Aurélien A Kohrt Holbrook H Levy Ronald R

Clinical cancer research : an official journal of the American Association for Cancer Research 20130821 19

Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe autoimmune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peritumoral delivery of low doses of this immunomodulatory drug can trigger a systemic antitumor immune response while preventing the toxicity against other organs. ...[more]

PMID: 23965900

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