Ontology highlight
ABSTRACT:
SUBMITTER: O'Brien EJ
PROVIDER: S-EPMC3817402 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
O'Brien Edward J EJ Lerman Joshua A JA Chang Roger L RL Hyduke Daniel R DR Palsson Bernhard Ø BØ
Molecular systems biology 20131001
Growth is a fundamental process of life. Growth requirements are well-characterized experimentally for many microbes; however, we lack a unified model for cellular growth. Such a model must be predictive of events at the molecular scale and capable of explaining the high-level behavior of the cell as a whole. Here, we construct an ME-Model for Escherichia coli--a genome-scale model that seamlessly integrates metabolic and gene product expression pathways. The model computes ~80% of the functiona ...[more]