Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone.
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ABSTRACT:
SUBMITTER: Wolfe KB
PROVIDER: S-EPMC3817667 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone.
Wolfe Katherine B KB Snyder Candice C CC Gisslen Tate T Kemp Matthew W MW Newnham John P JP Kramer Boris W BW Jobe Alan H AH Kallapur Suhas S
Reproductive sciences (Thousand Oaks, Calif.) 20130507 12
<h4>Objective</h4>We tested the hypothesis that the order of exposure to maternal betamethasone and intra-amniotic (IA) lipopolysaccharide (LPS) will differentially modulate inflammation in the chorioamnion.<h4>Study design</h4>Time-mated Merino ewes with singleton fetuses received saline alone, IA LPS alone, maternal betamethasone before LPS, or betamethasone after LPS. We assessed inflammatory markers in the chorioamnion and the amniotic fluid.<h4>Results</h4>Inflammatory cell infiltration, ex ...[more]
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