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Prospective single-site experience with radiofrequency-targeted vertebral augmentation for osteoporotic vertebral compression fracture.

ABSTRACT: Vertebral augmentation procedures are widely used to treat osteoporotic vertebral compression fractures (VCFs). We report our initial experience with radiofrequency-targeted vertebral augmentation (RF-TVA) in 20 patients aged 50 to 90 years with single-level, symptomatic osteoporotic VCF between T10 and L5, back pain severity >?4 on a 0 to 10 scale, Oswestry Disability Index ??21%, 20% to 90% vertebral height loss compared to adjacent vertebral body, and fracture age

SUBMITTER: Moser FG

PROVIDER: S-EPMC3817678 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Prospective single-site experience with radiofrequency-targeted vertebral augmentation for osteoporotic vertebral compression fracture.

Moser Franklin G FG Maya Marcel M MM Blaszkiewicz Laura L Scicli Andrea A Miller Larry E LE Block Jon E JE

Journal of osteoporosis 20131020

Vertebral augmentation procedures are widely used to treat osteoporotic vertebral compression fractures (VCFs). We report our initial experience with radiofrequency-targeted vertebral augmentation (RF-TVA) in 20 patients aged 50 to 90 years with single-level, symptomatic osteoporotic VCF between T10 and L5, back pain severity > 4 on a 0 to 10 scale, Oswestry Disability Index ≥ 21%, 20% to 90% vertebral height loss compared to adjacent vertebral body, and fracture age < 6 months. After treatment, ...[more]

PMID: 24228187

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Project description:BackgroundMost patients with osteoporotic vertebral compression fracture (OVCF) obtain pain relief after vertebral augmentation, but some will experience residual back pain (RBP) after surgery. Although several risk factors of RBP have been reported, it is still difficult to estimate the risk of RBP preoperatively. Radiomics is helpful for disease diagnosis and outcome prediction by establishing complementary relationships between human-recognizable and computer-extracted features. However, musculoskeletal radiomics investigations are less frequently reported.ObjectiveThis study aims to establish a radiomics score (rad-score) based nomogram for the preoperative prediction of RBP in OVCF patients.MethodsThe training cohort of 731 OVCF patients was used for nomogram development, and the validation cohort was utilized for performance test. RBP was determined as the score of visual analogue scale ≥ 4 at both 3 and 30 days following surgery. After normalization, the RBP-related radiomics features were selected to create rad-scores. These rad-scores, along with the RBP predictors initially identified by univariate analyses, were included in the multivariate analysis to establish a nomogram for the assessment of the RBP risk in OVCF patients preoperatively.ResultsA total of 81 patients (11.2%) developed RBP postoperatively. We finally selected 8 radiomics features from 1316 features extracted from each segmented image to determine the rad-score. Multivariate analysis revealed that the rad-score plus bone mineral density, intravertebral cleft, and thoracolumbar fascia injury were independent factors of RBP. Our nomograms based on these factors demonstrated good discrimination, calibration, and clinical utility in both training and validation cohorts. Furthermore, it achieved better performance than the rad-score itself, as well as the nomogram only incorporating regular features.ConclusionWe developed and validated a nomogram incorporating the rad-score and regular features for preoperative prediction of the RBP risk in OVCF patients, which contributed to improved surgical outcomes and patient satisfaction.

Dataset Information

Prospective single-site experience with radiofrequency-targeted vertebral augmentation for osteoporotic vertebral compression fracture.

Publications

Prospective single-site experience with radiofrequency-targeted vertebral augmentation for osteoporotic vertebral compression fracture.

Similar Datasets

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