Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors.
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SUBMITTER: Soares-Bezerra RJ
PROVIDER: S-EPMC3817725 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
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Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors.
Soares-Bezerra Rômulo José RJ Calheiros Andrea Surrage AS da Silva Ferreira Natiele Carla NC da Silva Frutuoso Valber V Alves Luiz Anastacio LA
Pharmaceuticals (Basel, Switzerland) 20130429 5
Natural products have reemerged in traditional medicine as a potential source of new molecules or phytomedicines to help with health disorders. It has been established that members of the P2X subfamily, ATP-gated ion channels, are crucial to the inflammatory process and pain signalization. As such, several preclinical studies have demonstrated that P2X2R, P2X3R, P2X4R and P2X7R are promising pharmacological targets to control inflammatory and pain disorders. Several studies have indicated that n ...[more]
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