Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC3817832 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Park Jun Hong JH Kang Hong Jun HJ Kang Soo Im SI Lee Ji Eun JE Hur Jamie J Ge Kai K Mueller Elisabetta E Li Hongjie H Lee Byeong-Chel BC Lee Sean Bong SB
Developmental cell 20130801 4
The recent surge in obesity has provided an impetus to better understand the mechanisms of adipogenesis, particularly in brown adipose tissue (BAT) because of its potential utilization for antiobesity therapy. Postnatal brown adipocytes arise from early muscle progenitors, but how brown fat lineage is determined is not completely understood. Here, we show that a multifunctional protein, Ewing Sarcoma (EWS), is essential for determining brown fat lineage during development. BATs from Ews null emb ...[more]