Ontology highlight
ABSTRACT:
SUBMITTER: Klosowiak JL
PROVIDER: S-EPMC3818075 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Klosowiak Julian L JL Focia Pamela J PJ Chakravarthy Srinivas S Landahl Eric C EC Freymann Douglas M DM Rice Sarah E SE
EMBO reports 20130927 11
Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation sit ...[more]