Varenicline for smoking cessation among methadone-maintained smokers: a randomized clinical trial.

ABSTRACT:

Background

With smoking rates far exceeding the general population, methadone-maintained (MMT) opiate-dependent smokers experience high rates of tobacco-related health consequences. Previous treatment studies have used nicotine replacement and produced low quit rates.

Methods

We test, using a three-group randomized design, the efficacy of varenicline versus placebo, in comparison with nicotine replacement therapy (NRT) that combines nicotine patch prescription plus ad libitum nicotine rescue, for smoking cessation. We recruited methadone-maintained smokers from nine treatment centers in southern New England and provided six months of treatment, and a minimal behavioral intervention at baseline (NCI's 5A's). Outcomes included carbon monoxide (CO) confirmed 7-day point smoking

SUBMITTER: Stein MD 

PROVIDER: S-EPMC3818400 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature