Obstructive renal injury: from fluid mechanics to molecular cell biology.
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ABSTRACT:
SUBMITTER: Ucero AC
PROVIDER: S-EPMC3818880 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Obstructive renal injury: from fluid mechanics to molecular cell biology.
Ucero Alvaro C AC Gonçalves Sara S Benito-Martin Alberto A Santamaría Beatriz B Ramos Adrian M AM Berzal Sergio S Ruiz-Ortega Marta M Egido Jesus J Ortiz Alberto A
Open access journal of urology 20100422
Urinary tract obstruction is a frequent cause of renal impairment. The physiopathology of obstructive nephropathy has long been viewed as a mere mechanical problem. However, recent advances in cell and systems biology have disclosed a complex physiopathology involving a high number of molecular mediators of injury that lead to cellular processes of apoptotic cell death, cell injury leading to inflammation and resultant fibrosis. Functional studies in animal models of ureteral obstruction using a ...[more]
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