Ontology highlight
ABSTRACT:
SUBMITTER: Weiwer M
PROVIDER: S-EPMC3818918 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
European journal of organic chemistry 20090601 16
α-Sialic acid azide <b>1</b> has been used as a substrate for the efficient preparation of 1,2,3-triazole derivatives of sialic acid using the copper-catalyzed azide-alkyne Huisgen cycloaddition ("click chemistry"). Our approach is to generate non-natural <i>N</i>-glycosides of sialic acid that are resistant to neuraminidase catalyzed hydrolysis as opposed to the natural <i>O</i>-glycosides. These <i>N</i>-glycosides would act as neuraminidase inhibitors to prevent the release of new virions. As ...[more]