Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis.

ABSTRACT:

Objective

Whereas circulating levels of C-reactive protein (CRP) have been associated with, for example, arterial stiffness, subclinical atherosclerosis and metabolic syndrome, other inflammatory biomarkers with potential interest for these conditions may not be measurable systemically. The predictive value of salivary biomarkers in these contexts has remained largely unexplored. The aim of the present study was to establish the association of different salivary biomarkers of inflammation with subclinical cardiovascular disease.

Methods

Two hundred and fifty-nine individuals were included in the study. Saliva and plasma samples were collected, and each individual underwent carotid ultrasound and measures of pulse wave velocity and blood pressure. Medical history of previous cardiovascular disease, current medications and smoking were collected by questionnaire.

Results

Salivary levels of CRP, leukotriene B4 (LTB4), prostaglandin E2 (PGE2), matrix metalloproteinase 9 (MMP-9), creatinine and lysozyme were measured. Salivary levels of CRP were significantly correlated with plasma levels (r?=?0.73, P?ConclusionSaliva may represent an alternative mean for evaluation of cardiovascular risk.

SUBMITTER: Labat C 

PROVIDER: S-EPMC3819311 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature