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Caffeine for the prevention of postoperative nausea and vomiting.


ABSTRACT: CONTEXT:Postoperative nausea and vomiting (PONV) is common after ambulatory surgery performed under general anesthesia. Anecdotal evidence suggests that caffeine may be useful in preventing PONV. AIMS:The aim of the study was to determine efficacy of intravenous (IV) caffeine given prior to surgery is effective prophylaxis against PONV. SETTINGS AND DESIGN:We conducted a prospective, randomized, double-blind, placebo-controlled study. SUBJECT AND METHODS:Patients at moderate or high risk of PONV were randomized to receive IV caffeine (500 mg) or saline placebo during general anesthesia; all patients received dexamethasone and dolasetron. STATISTICAL ANALYSIS:Statistical comparisons were tested using bivariable linear and logistic regression for each outcome and then adjusted for high/low risk. RESULTS:Nausea in the postanesthesia care unit (PACU) was more common in the caffeine (16 of 62 patients) than the placebo group (seven of 69; P = 0.02). There were no significant differences in the use of rescue antiemetics in the PACU, in the incidence of nausea or vomiting over 24 h postoperatively, nor in other outcomes (headache, fatigue, or overall satisfaction) either in the PACU or at 24 h; time-to-discharge was similar for both groups. CONCLUSION:Caffeine was not effective in the prevention of PONV or headache, and did not improve time-to-discharge or patient satisfaction.

SUBMITTER: Steinbrook RA 

PROVIDER: S-EPMC3819849 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Caffeine for the prevention of postoperative nausea and vomiting.

Steinbrook Richard A RA   Garfield Frances F   Batista Stacey H SH   Urman Richard D RD  

Journal of anaesthesiology, clinical pharmacology 20131001 4


<h4>Context</h4>Postoperative nausea and vomiting (PONV) is common after ambulatory surgery performed under general anesthesia. Anecdotal evidence suggests that caffeine may be useful in preventing PONV.<h4>Aims</h4>The aim of the study was to determine efficacy of intravenous (IV) caffeine given prior to surgery is effective prophylaxis against PONV.<h4>Settings and design</h4>We conducted a prospective, randomized, double-blind, placebo-controlled study.<h4>Subject and methods</h4>Patients at  ...[more]

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