Ontology highlight
ABSTRACT:
SUBMITTER: Park SL
PROVIDER: S-EPMC3819900 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Park Sung Lyea SL Lee Bo Kyung BK Kim Young-Ae YA Lee Byung Ho BH Jung Yi-Sook YS
Biomolecules & therapeutics 20130701 4
In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926) and human monocytes (U937). UII induced inflammatory activation of endothelial cells through expression of proinflammatory cytokines (IL-1β and IL-6), adhesion molecules (VCAM-1), and tissue factor (TF), which facilitates the adhesion of monocytes to EA.hy926 cells. Treatment with SB-657510 si ...[more]