Ontology highlight
ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC3819944 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Ren Junping J Kolli Deepthi D Deng Junfang J Fang Rong R Gong Bin B Xue Megan M Casola Antonella A Garofalo Roberto P RP Wang Tian T Bao Xiaoyong X
Virus research 20130708 1-2
Human metapneumovirus (hMPV) is a common cause of lung and airway infections in infants and young children. Recently, we and others have shown that hMPV infection induces Toll-like receptor (TLR)-dependent cellular signaling. However, the contribution of TLR-mediated signaling in host defenses against pulmonary hMPV infection and associated disease pathogenesis has not been elucidated. In this study, mice deficient in MyD88, a common adaptor of TLRs, was used to investigate the contribution of T ...[more]