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Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-?-Pyrones from the Marine Actinomycete Salinispora arenicola.


ABSTRACT: Six new anthraquinone-?-pyrones, saliniquinones A-F (1-6), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete Salinispora arenicola (strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds 1-6 were determined by analysis of NOESY NMR spectroscopic data and by comparison of circular dichroism and optical rotation data with model compounds found in the literature. Saliniquinone A (1) exhibited potent inhibition of the human colon adenocarcinoma cell line (HCT-116) with an IC50 of 9.9 × 10-9 M. In the context of the biosynthetic diversity of S. arenicola, compounds 1-6 represent secondary metabolites that appear to be strain specific and thus occur outside of the core group of compounds commonly observed from this species.

SUBMITTER: Murphy BT 

PROVIDER: S-EPMC3820018 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete <i>Salinispora arenicola.</i>

Murphy Brian T BT   Narender Tadigoppula T   Kauffman Christopher A CA   Woolery Matthew M   Jensen Paul R PR   Fenical William W  

Australian journal of chemistry 20100601 6


Six new anthraquinone-γ-pyrones, saliniquinones A-F (<b>1</b>-<b>6</b>), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete <i>Salinispora arenicola</i> (strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds <b>1</b>-<b>6</b> were determined by analysis of NOESY  ...[more]

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