Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida H
PROVIDER: S-EPMC3821019 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
FEBS open bio 20130817
Recently, we have disclosed that human KIAA1199 (hKIAA1199) is a hyaluronan (HA) binding protein implicated in HA depolymerization. Although a murine homologue (mKiaa1199) was previously cloned, no information about the function of the molecule was available. Here, we show that cells transfected with mKiaa1199 cDNA selectively catabolized HA via the clathrin-coated pit pathway. A glycosaminoglycan-binding assay demonstrated the specific binding of mKiaa1199 to HA. These results were similar to o ...[more]