Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara T
PROVIDER: S-EPMC3821025 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Fujiwara Tohru T Okitsu Yoko Y Katsuoka Yuna Y Fukuhara Noriko N Onishi Yasushi Y Ishizawa Kenichi K Harigae Hideo H
FEBS open bio 20131011
ETO2 is a component of a protein complex containing master regulators of hematopoiesis, including GATA-1 and SCL/TAL1, and also has RNA binding properties. Although ETO2 has been reported to repress GATA-1 target genes through histone deacetylation of the target gene loci in erythroid cells, little is known about the contribution of ETO2 to microRNA (miRNA) regulation. Here, we conducted miRNA profiling in ETO2-overexpressing and ETO2-silenced K562 cells. The analysis suggests that ETO2 positive ...[more]