Ontology highlight
ABSTRACT:
SUBMITTER: Perez RJ
PROVIDER: S-EPMC3821387 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Pérez Ronald J RJ Benoit Yannick D YD Gudas Lorraine J LJ
Experimental cell research 20130610 14
All-trans retinoic acid (RA) signals via binding to retinoic acid receptors (RARs α, β, and γ). RA directly influences expression of Pdx1, a transcription factor essential for pancreatic development and beta-cell (β-cell) maturation. In this study we follow the differentiation of cultured wild-type (WT) vs. RARβ knockout (KO) embryonic stem (ES) cells into pancreatic islet cells. We found that RARβ KO ES cells show greatly reduced expression of some important endocrine markers of differentiated ...[more]