Ontology highlight
ABSTRACT:
SUBMITTER: Bianco AC
PROVIDER: S-EPMC3821470 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Bianco Antonio C AC Casula Sabina S
European thyroid journal 20120627 2
Current guidelines recommend that hypothyroid patients should be treated with levothyroxine, which in the vast majority of the cases leads to resolution of the symptoms and normalization of serum free T4 (FT4), T3 and TSH levels. However, a small group of hypothyroid patients remain symptomatic for neurocognitive dysfunction despite normal serum FT4 and TSH, which could be explained by localized brain hypothyroidism. More than half of the T3 in the brain is produced locally via the action of the ...[more]