Ontology highlight
ABSTRACT:
SUBMITTER: Pettem KL
PROVIDER: S-EPMC3821696 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Pettem Katherine L KL Yokomaku Daisaku D Luo Lin L Linhoff Michael W MW Prasad Tuhina T Connor Steven A SA Siddiqui Tabrez J TJ Kawabe Hiroshi H Chen Fang F Zhang Ling L Rudenko Gabby G Wang Yu Tian YT Brose Nils N Craig Ann Marie AM
Neuron 20131002 1
Perturbations of cell surface synapse-organizing proteins, particularly α-neurexins, contribute to neurodevelopmental and psychiatric disorders. From an unbiased screen, we identify calsyntenin-3 (alcadein-β) as a synapse-organizing protein unique in binding and recruiting α-neurexins, but not β-neurexins. Calsyntenin-3 is present in many pyramidal neurons throughout cortex and hippocampus but is most highly expressed in interneurons. The transmembrane form of calsyntenin-3 can trigger excitator ...[more]