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Engineering new protein-protein interactions on the ?-propeller fold by yeast cell surface display.


ABSTRACT: REINVENTING THE WHEEL: The ?-propeller domain folds like a wheel to provide key protein-protein interactions in the cell. Here we used high-throughput yeast sorting to "invent" ?-propellers of new binding specificities with cellular targets.

SUBMITTER: Zhang K 

PROVIDER: S-EPMC3822001 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Engineering new protein-protein interactions on the β-propeller fold by yeast cell surface display.

Zhang Keya K   Li Heng H   Bhuripanyo Karan K   Zhao Bo B   Chen Tiffany F TF   Zheng Ning N   Yin Jun J  

Chembiochem : a European journal of chemical biology 20130210 4


REINVENTING THE WHEEL: The β-propeller domain folds like a wheel to provide key protein-protein interactions in the cell. Here we used high-throughput yeast sorting to "invent" β-propellers of new binding specificities with cellular targets. ...[more]

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