Ontology highlight
ABSTRACT:
SUBMITTER: McLaughlin SK
PROVIDER: S-EPMC3822334 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
McLaughlin Sara Koenig SK Olsen Sarah Naomi SN Dake Benjamin B De Raedt Thomas T Lim Elgene E Bronson Roderick Terry RT Beroukhim Rameen R Polyak Kornelia K Brown Myles M Kuperwasser Charlotte C Cichowski Karen K
Cancer cell 20130901 3
RAS genes are commonly mutated in cancer; however, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and ERK. Here, we report that the RasGAP gene, RASAL2, functions as a tumor and metastasis suppressor. RASAL2 is mutated or suppressed in human breast cancer, and RASAL2 ablation promotes tumor growth, progression, and metastasis in mouse models. In human breast cancer, RASAL2 loss is associated with metastatic disease; low RASAL2 levels correlate with recurrence of ...[more]