Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke.
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ABSTRACT:
SUBMITTER: Suzuki Y
PROVIDER: S-EPMC3822396 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
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Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke.
Suzuki Yukiya Y Nakano Yusuke Y Mishiro Keisuke K Takagi Toshinori T Tsuruma Kazuhiro K Nakamura Mitsuhiro M Yoshimura Shinichi S Shimazawa Masamitsu M Hara Hideaki H
Scientific reports 20131111
Accumulating evidence shows that post-ischemic inflammation originated by Toll-like receptors (TLR) plays critical roles in ischemic stroke. However, the functions of other innate immune receptors are poorly understood in cerebral ischemia. Macrophage-inducible C-type lectin, Mincle, is one of the innate immune receptor C-type lectin-like receptor (CLR) to response against dying cells. In the present study, we showed that Mincle, its ligand SAP130, and its downstream phospho-Syk/Syk were upregul ...[more]
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