Ontology highlight
ABSTRACT:
SUBMITTER: Meza-Zepeda LA
PROVIDER: S-EPMC3822542 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Meza-Zepeda Leonardo A LA Noer Agate A Dahl John Arne JA Micci Francesca F Myklebost Ola O Collas Philippe P
Journal of cellular and molecular medicine 20080401 2
The potential use of human mesenchymal stem cells for therapeutic applications implies large scale in vitro culture, increasing the probability of genetic instability and transformation. We examine here the incidence of unbalanced and balanced chromosome rearrangements in polyclonal and single cell-derived cultures of human adipose stem cells to senescence. G-banding karyotyping of the polyclonal cultures shows a normal karyotype. In addition, high-resolution microarray-based comparative genomic ...[more]