Ontology highlight
ABSTRACT:
SUBMITTER: Chen YF
PROVIDER: S-EPMC3822768 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Chen Yi-Fong YF Lin Yi-Chien YC Huang Po-Kai PK Chan Hsu-Chin HC Kuo Sheng-Chu SC Lee Kuo-Hsiung KH Huang Li-Jiau LJ
Bioorganic & medicinal chemistry 20130626 17
Novel 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives 12a-n were designed and prepared through an intramolecular cyclization reaction and evaluated for in vitro anticancer activity. Among the synthesized compounds, 6,7-methylenedioxy-4-(2,4-dimethoxyphenyl)quinolin-2(1H)-one (12e) displayed potent cytotoxicity against several different tumor cell lines at a sub-micromolar level. Furthermore, results of fluorescence-activated cell sorting (FACS) analysis suggested that 12e i ...[more]