Ontology highlight
ABSTRACT:
SUBMITTER: Bilsland AE
PROVIDER: S-EPMC3822786 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Bilsland Alan E AE Cairney Claire J CJ Keith W Nicol WN
Journal of cellular and molecular medicine 20110201 2
Aberrant telomere homeostasis is essential for cell immortality, enabling cells to evade telomere dependent senescence. Disruption of telomere structure and function in cancer cells is highly toxic as shown by detailed pre-clinical evaluation of telomerase inhibitors. Under telomerase inhibition, cells must divide sufficiently frequently to allow one or more telomeres to shorten to an unprotected length. Functioning telomeres are disguised from the DNA damage machinery by DNA remodelling and oth ...[more]