Ontology highlight
ABSTRACT:
SUBMITTER: Krashes MJ
PROVIDER: S-EPMC3822903 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Krashes Michael J MJ Shah Bhavik P BP Koda Shuichi S Lowell Bradford B BB
Cell metabolism 20131001 4
Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA agonist results in the marked escalation of food consumption with temporal variance. Given the orexigenic capability of all three of these neuroactive ...[more]