Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
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ABSTRACT:
SUBMITTER: Price KE
PROVIDER: S-EPMC3822904 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Price K E KE Pearce R E RE Garg U C UC Heese B A BA Smith L D LD Sullivan J E JE Kennedy M J MJ Bale J F JF Ward R M RM Chang T K H TK Abbott F S FS Leeder J S JS
Clinical pharmacology and therapeutics 20110504 6
Young children are at increased risk for valproic acid (VPA) hepatotoxicity. Urinary organic acid profiles, as a surrogate of mitochondrial function, were obtained in children 1.9 to 17.3 years of age (n = 52) who were undergoing treatment with VPA for seizure disorders. Age-matched patients receiving treatment with carbamazepine (CBZ; n = 50) and healthy children not undergoing treatment (n = 22) served as controls. Age-related changes in organic acid profiles were observed in all three groups. ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below.
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