Ontology highlight
ABSTRACT:
SUBMITTER: Hiltunen M
PROVIDER: S-EPMC3823075 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Hiltunen Mikko M Khandelwal Vinoth K M VK Yaluri Nagendra N Tiilikainen Tea T Tusa Maija M Koivisto Henna H Krzisch Marine M Vepsäläinen Saila S Mäkinen Petra P Kemppainen Susanna S Miettinen Pasi P Haapasalo Annakaisa A Soininen Hilkka H Laakso Markku M Tanila Heikki H
Journal of cellular and molecular medicine 20120601 6
According to epidemiological studies, type-2 diabetes increases the risk of Alzheimer's disease. Here, we induced hyperglycaemia in mice overexpressing mutant amyloid precursor protein and presenilin-1 (APdE9) either by cross-breeding them with pancreatic insulin-like growth factor 2 (IGF-2) overexpressing mice or by feeding them with high-fat diet. Glucose and insulin tolerance tests revealed significant hyperglycaemia in mice overexpressing IGF-2, which was exacerbated by high-fat diet. Howeve ...[more]