Ontology highlight
ABSTRACT:
SUBMITTER: Vos M
PROVIDER: S-EPMC3823844 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Vos Melissa M Lovisa Blaise B Geens Ann A Morais Vanessa A VA Wagnières Georges G van den Bergh Hubert H Ginggen Alec A De Strooper Bart B Tardy Yanik Y Verstreken Patrik P
PloS one 20131111 11
Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypothesis that 808 nm infrared light that effectively penetrates tissues rescues pink1 mutants. We show that irradiating isolated fly or mouse mitochondria with 808 nm light that is absorbed by ETC-Complex IV acutely improves Complex IV-dependent o ...[more]