Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

ABSTRACT: It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successfu

SUBMITTER: Dodds CM 

PROVIDER: S-EPMC3823923 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature