Ontology highlight
ABSTRACT:
SUBMITTER: Edwards SL
PROVIDER: S-EPMC3824120 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Edwards Stacey L SL Beesley Jonathan J French Juliet D JD Dunning Alison M AM
American journal of human genetics 20131101 5
Genome-wide association studies (GWASs) have enabled the discovery of common genetic variation contributing to normal and pathological traits and clinical drug responses, but recognizing the precise targets of these associations is now the major challenge. Here, we review recent approaches to the functional follow-up of GWAS loci, including fine mapping of GWAS signal(s), prioritization of putative functional SNPs by the integration of genetic epidemiological and bioinformatic methods, and in vi ...[more]