Ontology highlight
ABSTRACT:
SUBMITTER: Rah JC
PROVIDER: S-EPMC3824245 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rah Jong-Cheol JC Bas Erhan E Colonell Jennifer J Mishchenko Yuriy Y Karsh Bill B Fetter Richard D RD Myers Eugene W EW Chklovskii Dmitri B DB Svoboda Karel K Harris Timothy D TD Isaac John T R JT
Frontiers in neural circuits 20131112
The subcellular locations of synapses on pyramidal neurons strongly influences dendritic integration and synaptic plasticity. Despite this, there is little quantitative data on spatial distributions of specific types of synaptic input. Here we use array tomography (AT), a high-resolution optical microscopy method, to examine thalamocortical (TC) input onto layer 5 pyramidal neurons. We first verified the ability of AT to identify synapses using parallel electron microscopic analysis of TC synaps ...[more]