Ontology highlight
ABSTRACT:
SUBMITTER: Henry RA
PROVIDER: S-EPMC3824617 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Henry Rachel A RA Kendall Peggy L PL
Journal of immunology (Baltimore, Md. : 1950) 20100623 3
Lymphocytes that invade nonlymphoid tissues often organize into follicle-like structures known as tertiary lymphoid organs (TLOs). These structures resemble those found in spleen or lymph nodes, but their function is unknown. TLOs are recognized in many autoimmune diseases, including the NOD mouse model of type 1 diabetes. In some cases, TLOs have been associated with the B lymphocyte chemoattractant, CXCL13. Studies presented in this article show that CXCL13 is present in inflamed islets of NOD ...[more]