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A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.

ABSTRACT: Chronic otitis media with effusion (COME) and recurrent otitis media (ROM) have been shown to be heritable, but candidate gene and linkage studies to date have been equivocal. Our aim was to identify genetic susceptibility factors using a genome-wide association study (GWAS). We genotyped 602 subjects from 143 families with 373 COME/ROM subjects using the Illumina Human CNV370-Duo DNA Bead Chip (324,748 SNPs). We carried out the GWAS scan and imputed SNPs at the regions with the most significant associations. Replication genotyping in an independent family-based sample was conducted for 53 SNPs: the 41 most significant SNPs with P?

SUBMITTER: Allen EK 

PROVIDER: S-EPMC3825021 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.

Allen E Kaitlynn EK   Chen Wei-Min WM   Weeks Daniel E DE   Chen Fang F   Hou Xuanlin X   Mattos José L JL   Mychaleckyj Josyf C JC   Segade Fernando F   Casselbrant Margaretha L ML   Mandel Ellen M EM   Ferrell Robert E RE   Rich Stephen S SS   Daly Kathleen A KA   Sale Michèle M MM  

Journal of the Association for Research in Otolaryngology : JARO 20130823 6

Chronic otitis media with effusion (COME) and recurrent otitis media (ROM) have been shown to be heritable, but candidate gene and linkage studies to date have been equivocal. Our aim was to identify genetic susceptibility factors using a genome-wide association study (GWAS). We genotyped 602 subjects from 143 families with 373 COME/ROM subjects using the Illumina Human CNV370-Duo DNA Bead Chip (324,748 SNPs). We carried out the GWAS scan and imputed SNPs at the regions with the most significant  ...[more]

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2019-01-24 | GSE125532 | GEO