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Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.

ABSTRACT: The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review aims to provide an overview of FGFR family, their complex signaling pathways in tumorigenesis, and the current development and application of therapeutics targeting the FGFRs signaling for treatment of refractory human cancers.

SUBMITTER: Tiong KH 

PROVIDER: S-EPMC3825415 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.

Tiong Kai Hung KH   Mah Li Yen LY   Leong Chee-Onn CO  

Apoptosis : an international journal on programmed cell death 20131201 12

The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review aims to provide an overview of FGFR family, their complex signaling pathways in tumorigenesis, and the current development and application of therapeuti  ...[more]

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