Ontology highlight
ABSTRACT:
SUBMITTER: Hattori T
PROVIDER: S-EPMC3825457 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hattori Tomoyasu T Stawski Lukasz L Nakerakanti Sashidhar S SS Trojanowska Maria M
The Journal of investigative dermatology 20110331 7
Estrogen is an important regulator of dermal fibroblast functions, including extracellular matrix (ECM) synthesis. Estrogen mediates its effects through estrogen receptors (ERs), ERα and ERβ; however, regulation of ERs in dermal fibroblasts remains poorly understood. Friend leukemia integration factor 1 (Fli1), a member of the Ets transcription factor family, has been shown to play a pivotal role in regulation of the ECM genes in dermal fibroblasts. The aim of this study was to examine a possibl ...[more]