Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.
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ABSTRACT:
SUBMITTER: Danckwardt S
PROVIDER: S-EPMC3825489 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.
Danckwardt Sven S Hentze Matthias W MW Kulozik Andreas E AE
Journal of molecular medicine (Berlin, Germany) 20130817 11
Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions that reach far beyond its well-established role in stemming blood loss and thrombosis, including embryonic development and angiogenesis but also extending to inflammatory processes, complement activa ...[more]
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