Ontology highlight
ABSTRACT:
SUBMITTER: Bharali DJ
PROVIDER: S-EPMC3825799 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Bharali Dhruba J DJ Yalcin Murat M Davis Paul J PJ Mousa Shaker A SA
Nanomedicine (London, England) 20130228 12
<h4>Aim</h4>The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer.<h4>Materials & methods</h4>The uptake of tetrac and T-PLGA-NPs in doxorubicin-resistant MCF7 (MCF7-Dx) cells was evaluated using confocal microscopy. Cell proliferation assays and a chick chorioallantoic membrane model of FGF2-induced angio ...[more]