Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Cordero A
PROVIDER: S-EPMC3826328 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Gonzalez-Cordero Anai A West Emma L EL Pearson Rachael A RA Duran Yanai Y Carvalho Livia S LS Chu Colin J CJ Naeem Arifa A Blackford Samuel J I SJI Georgiadis Anastasios A Lakowski Jorn J Hubank Mike M Smith Alexander J AJ Bainbridge James W B JWB Sowden Jane C JC Ali Robin R RR
Nature biotechnology 20130721 8
Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy. We previously demonstrated retinal repair and restoration of vision through transplantation of photoreceptor precursors obtained from postnatal retinas into visually impaired adult mice. Considerable progress has been made in differentiating embryonic stem cells (ESCs) in vitro toward photoreceptor lineages. However, the capability of ESC-derived photoreceptors to integrate after transplantation has not been ...[more]