Ontology highlight
ABSTRACT:
SUBMITTER: Guo SL
PROVIDER: S-EPMC3826643 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Guo Shui-Long SL Ye Hui H Teng Yan Y Wang You-Liang YL Yang Guan G Li Xiu-Bin XB Zhang Chong C Yang Xue X Yang Zhong-Zhou ZZ Yang Xiao X
Nature communications 20130101
Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation of PTEN in mouse gastric epithelium initiates spontaneous carcinogenesis with complete penetrance by 2 months of age. Mechanistically, activation of Akt suppresses the abundance of p53, leading to decreased transcription of miR-365, thus causing upregulation of cyclin D1 and cdc25A, whi ...[more]