Ontology highlight
ABSTRACT:
SUBMITTER: Smith MD
PROVIDER: S-EPMC3826745 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Smith M Duane MD Gu Yu Y Querol-Audí Jordi J Vogan Jacob M JM Nitido Adam A Cate Jamie H D JH
PloS one 20131108 11
Eukaryotic translation initiation factor 3 (eIF3) is a key regulator of translation initiation, but its in vivo assembly and molecular functions remain unclear. Here we show that eIF3 from Neurospora crassa is structurally and compositionally similar to human eIF3. N. crassa eIF3 forms a stable 12-subunit complex linked genetically and biochemically to the 13(th) subunit, eIF3j, which in humans modulates mRNA start codon selection. Based on N. crassa genetic analysis, most subunits in eIF3 are e ...[more]