Ontology highlight
ABSTRACT:
SUBMITTER: Qiang X
PROVIDER: S-EPMC3826915 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Qiang Xiaoling X Yang Weng-Lang WL Wu Rongqian R Zhou Mian M Jacob Asha A Dong Weifeng W Kuncewitch Michael M Ji Youxin Y Yang Huan H Wang Haichao H Fujita Jun J Nicastro Jeffrey J Coppa Gene F GF Tracey Kevin J KJ Wang Ping P
Nature medicine 20131006 11
A systemic inflammatory response is observed in patients undergoing hemorrhagic shock and sepsis. Here we report increased levels of cold-inducible RNA-binding protein (CIRP) in the blood of individuals admitted to the surgical intensive care unit with hemorrhagic shock. In animal models of hemorrhage and sepsis, CIRP is upregulated in the heart and liver and released into the circulation. In macrophages under hypoxic stress, CIRP translocates from the nucleus to the cytosol and is released. Rec ...[more]