Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC3827076 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhang Chengwan C Hong Zehui Z Ma Wencui W Ma Da D Qian Yuchen Y Xie Wei W Tie Feng F Fang Ming M
PloS one 20131112 11
UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae. We further showed that UTX mediates the expression of ku80 by the demethylation of H3K27me3 at the ku80 promoter upon exposure to ionizing radiation (IR) in a p53-dependent manner. UTX interacts physically with p53, ...[more]