Genome wide analysis of fertility and production traits in Italian Holstein cattle.
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ABSTRACT:
SUBMITTER: Minozzi G
PROVIDER: S-EPMC3827211 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Genome wide analysis of fertility and production traits in Italian Holstein cattle.
Minozzi Giulietta G Nicolazzi Ezequiel L EL Stella Alessandra A Biffani Stefano S Negrini Riccardo R Lazzari Barbara B Ajmone-Marsan Paolo P Williams John L JL
PloS one 20131112 11
A genome wide scan was performed on a total of 2093 Italian Holstein proven bulls genotyped with 50K single nucleotide polymorphisms (SNPs), with the objective of identifying loci associated with fertility related traits and to test their effects on milk production traits. The analysis was carried out using estimated breeding values for the aggregate fertility index and for each trait contributing to the index: angularity, calving interval, non-return rate at 56 days, days to first service, and ...[more]
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Project description:Using genomic data, lethal recessives may be discovered from haplotypes that are common in the population but never occur in the homozygote state in live animals. This approach only requires genotype data from phenotypically normal (i.e. live) individuals and not from the affected embryos that die. A total of 7,937 Nordic Holstein animals were genotyped with BovineSNP50 BeadChip and haplotypes including 25 consecutive markers were constructed and tested for absence of homozygotes states. We have identified 17 homozygote deficient haplotypes which could be loosely clustered into eight genomic regions harboring possible recessive lethal alleles. Effects of the identified haplotypes were estimated on two fertility traits: non-return rates and calving interval. Out of the eight identified genomic regions, six regions were confirmed as having an effect on fertility. The information can be used to avoid carrier-by-carrier mattings in practical animal breeding. Further, identification of causative genes/polymorphisms responsible for lethal effects will lead to accurate testing of the individuals carrying a lethal allele.
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