Ontology highlight
ABSTRACT:
SUBMITTER: Vanderheyden WM
PROVIDER: S-EPMC3828275 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Vanderheyden William M WM Gerstner Jason R JR Tanenhaus Anne A Yin Jerry C JC Shaw Paul J PJ
PloS one 20131114 11
Given the relationship between sleep and plasticity, we examined the role of Extracellular signal-regulated kinase (ERK) in regulating baseline sleep, and modulating the response to waking experience. Both sleep deprivation and social enrichment increase ERK phosphorylation in wild-type flies. The effects of both sleep deprivation and social enrichment on structural plasticity in the LNvs can be recapitulated by expressing an active version of ERK (UAS-ERK(SEM)) pan-neuronally in the adult fly u ...[more]