Ontology highlight
ABSTRACT:
SUBMITTER: Park RJ
PROVIDER: S-EPMC3828596 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Park Ryan J RJ Shen Hongying H Liu Lijuan L Liu Xinran X Ferguson Shawn M SM De Camilli Pietro P
Journal of cell science 20130917 Pt 22
Dynamin, which is encoded by three genes in mammals, is a GTPase implicated in endocytic membrane fission. Dynamin 1 and 3 are predominantly expressed in brain, whereas dynamin 2 is ubiquitously expressed. With the goal of assessing the impact of the lack of dynamin on cell physiology, we previously generated and characterized dynamin 1 and 2 double knockout (DKO) fibroblasts. These DKO cells were unexpectedly viable in spite of a severe impairment of clathrin-mediated endocytosis. As low-level ...[more]