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Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study.


ABSTRACT: Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

SUBMITTER: Vavere AL 

PROVIDER: S-EPMC3828643 | biostudies-literature | 2011 Nov-Dec

REPOSITORIES: biostudies-literature

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Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study.

Vavere Andrea L AL   Simon Gregory G GG   George Richard T RT   Rochitte Carlos E CE   Arai Andrew E AE   Miller Julie M JM   Di Carli Marcello M   Arbab-Zadeh Armin A   Dewey Marc M   Niinuma Hiroyuki H   Laham Roger R   Rybicki Frank J FJ   Schuijf Joanne D JD   Paul Narinder N   Hoe John J   Kuribyashi Sachio S   Sakuma Hajime H   Nomura Cesar C   Yaw Tan Swee TS   Kofoed Klaus F KF   Yoshioka Kunihiro K   Clouse Melvin E ME   Brinker Jeffrey J   Cox Christopher C   Lima Joao A C JA  

Journal of cardiovascular computed tomography 20111112 6


Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomograp  ...[more]

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